01808nam a2200277Ia 4500 TVU_11444 210423s9999 xx 000 0 und d 019515066X 9780195150667 eng 579.378 D249 Hopwood, David A. Streptomyces in nature and medicine the antibiotic makers David A. Hopwood Oxford,New York Oxford University Press 2007 viii, 250 p. ill. 25 cm The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then come an up-to-the minute account of the use of genetic engineering to make novel, hybrid, antibiotics, and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic productivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens Streptomyces; Genetic Engineering David A. Hopwood Trung tâm Học liệu Trường Đại học Trà Vinh