Stochastic simulation of DNA double-strand break repair by non-homologous end joining based on track structure calculations /

Míreanna Comhchosúla

• Homologous recombination contributes to the repair of DNA double-strand breaks induced by high-energy iron ions /
• Extensive repair of DNA double-strand breaks in cells deficient in the DNA-PK-dependent pathway of NHEJ after exclusion of heat-labile sites /
• Distribution of double-strand breaks induced by ionizing radiation at the level of single DNA molecules examined by atomic force microscopy /
• 5,6-dihydrothymine impairs the base excision repair pathway of a closely opposed AP site or single-strand break /
• Single-strand annealing, conservative homologous recombination, nonhomologous DNA end joining, the cell cycle-dependent repair of DNA double-strand breaks induced by sparsely or densely ionizing radiation /