Ancestral sequence reconstruction
Ancestral sequence reconstruction is a technique of growing importance in molecular biology and comparative genomics. As a powerful technique for both testing evolutionary and ecological hypotheses as well as uncovering the link between sequence and molecular phenotype, there are potential applicati...
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| Tác giả khác: | |
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| Ngôn ngữ: | Undetermined English |
| Được phát hành: |
Oxford,New York
Oxford University Press
2007
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| Những chủ đề: | |
| Các nhãn: |
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| Thư viện lưu trữ: | Trung tâm Học liệu Trường Đại học Trà Vinh |
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| LEADER | 01893nam a2200265Ia 4500 | ||
|---|---|---|---|
| 001 | TVU_13195 | ||
| 008 | 210423s9999 xx 000 0 und d | ||
| 020 | |a 0199299188 | ||
| 020 | |a 9780199299188 | ||
| 041 | |a eng | ||
| 082 | |a 572.838 | ||
| 082 | |b D111 | ||
| 245 | 0 | |a Ancestral sequence reconstruction | |
| 245 | 0 | |c edited by David A. Liberles | |
| 260 | |a Oxford,New York | ||
| 260 | |b Oxford University Press | ||
| 260 | |c 2007 | ||
| 300 | |a xiii, 252 p. | ||
| 300 | |b ill. | ||
| 300 | |c 26 cm | ||
| 504 | |a Includes bibliographical references and index | ||
| 520 | |a Ancestral sequence reconstruction is a technique of growing importance in molecular biology and comparative genomics. As a powerful technique for both testing evolutionary and ecological hypotheses as well as uncovering the link between sequence and molecular phenotype, there are potential applications in a number of fields. Beginning with a historical overview of the field including apllications, the discussion then moves into potential applications in drug discovery and the pharmaceutical industry. A section on computational methodology provides a detailed discussion on available methods for reconstructing ancestral sequences, including advantages,disadvantages, and potential pitfalls. Purely computational applications, including whole proteome reconstruction are discussed. Another section provides a detailed discussion on taking computationally reconstructed sequences and synthesizing them in the laboratory, while the last section describes scientific questions where experimental ancestral sequence reconstruction coupled to a computaional and experimental how-to guide, while simultaneously addressing some of the hot topics in the field | ||
| 650 | |a Nucleotide sequence; Evolutionary genetics | ||
| 700 | |a edited by David A. Liberles | ||
| 980 | |a Trung tâm Học liệu Trường Đại học Trà Vinh | ||