Genome and evolution of the shade-requiring medicinal herb Panax ginseng
Panax ginseng C. A. Meyer, reputed as the king of medicinal herbs, has slow growth, long generation time, low seed production and complicated genome structure that hamper its study. Here, we unveil the genomic architecture of tetraploid P. ginseng by de novo genome assembly, representing 2.98 Gbp wi...
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2022
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oai:scholar.dlu.edu.vn:123456789-13132022-10-12T08:34:04Z Genome and evolution of the shade-requiring medicinal herb Panax ginseng Kim, Nam-Hoon Jayakodi, Murukarthick Lee, Sang-Choon Choi, Beom-Soon Jang, Woojong Lee, Junki Kim, Hyun Hee Waminal, Nomar E Lakshmanan, Meiyappan Nguyễn, Văn Bình Lee, Yun Sun Park, Hyun-Seung Koo, Hyun Jo Park, Jee Young Perumal, Sampath Joh, Ho Jun Lee, Hana Kim, Jinkyung Kim, In Seo Kim, Kyunghee Koduru, Lokanand Kang, Kyo Bin Sung, Sang Hyun Yu, Yeisoo Park, Daniel S Choi, Doil Seo, Eunyoung Kim, Seungill Kim, Young-Chang Hyun, Dong Yun Park, Youn-Il Kim, Changsoo Lee, Tae-Ho Kim, Hyun Uk Soh, Moon Soo Lee, Yi In, Jun Gyo Kim, Heui-Soo Kim, Yong-Min Yang, Deok-Chun Wing, Rod A Lee, Dong-Yup Paterson, Andrew H Yang, Tae-Jin Panax ginseng; adaptation; evolution; ginsenosides; metabolic network Panax ginseng C. A. Meyer, reputed as the king of medicinal herbs, has slow growth, long generation time, low seed production and complicated genome structure that hamper its study. Here, we unveil the genomic architecture of tetraploid P. ginseng by de novo genome assembly, representing 2.98 Gbp with 59 352 annotated genes. Resequencing data indicated that diploid Panax species diverged in association with global warming in Southern Asia, and two North American species evolved via two intercontinental migrations. Two whole genome duplications (WGD) occurred in the family Araliaceae (including Panax) after divergence with the Apiaceae, the more recent one contributing to the ability of P. ginseng to overwinter, enabling it to spread broadly through the Northern Hemisphere. Functional and evolutionary analyses suggest that production of pharmacologically important dammarane-type ginsenosides originated in Panax and are produced largely in shoot tissues and transported to roots; that newly evolved P. ginseng fatty acid desaturases increase freezing tolerance; and that unprecedented retention of chlorophyll a/b binding protein genes enables efficient photosynthesis under low light. A genome-scale metabolic network provides a holistic view of Panax ginsenoside biosynthesis. This study provides valuable resources for improving medicinal values of ginseng either through genomics-assisted breeding or metabolic engineering. 2022-10-12T08:34:00Z 2022-10-12T08:34:00Z 2018 Journal article Bài báo đăng trên tạp chí thuộc ISI, bao gồm book chapter http://scholar.dlu.edu.vn/handle/123456789/1313 10.1111/pbi.12926 29604169 en Plant biotechnology journal |
| institution |
Thư viện Trường Đại học Đà Lạt |
| collection |
Thư viện số |
| language |
English |
| topic |
Panax ginseng; adaptation; evolution; ginsenosides; metabolic network |
| spellingShingle |
Panax ginseng; adaptation; evolution; ginsenosides; metabolic network Kim, Nam-Hoon Jayakodi, Murukarthick Lee, Sang-Choon Choi, Beom-Soon Jang, Woojong Lee, Junki Kim, Hyun Hee Waminal, Nomar E Lakshmanan, Meiyappan Nguyễn, Văn Bình Lee, Yun Sun Park, Hyun-Seung Koo, Hyun Jo Park, Jee Young Perumal, Sampath Joh, Ho Jun Lee, Hana Kim, Jinkyung Kim, In Seo Kim, Kyunghee Koduru, Lokanand Kang, Kyo Bin Sung, Sang Hyun Yu, Yeisoo Park, Daniel S Choi, Doil Seo, Eunyoung Kim, Seungill Kim, Young-Chang Hyun, Dong Yun Park, Youn-Il Kim, Changsoo Lee, Tae-Ho Kim, Hyun Uk Soh, Moon Soo Lee, Yi In, Jun Gyo Kim, Heui-Soo Kim, Yong-Min Yang, Deok-Chun Wing, Rod A Lee, Dong-Yup Paterson, Andrew H Yang, Tae-Jin Genome and evolution of the shade-requiring medicinal herb Panax ginseng |
| description |
Panax ginseng C. A. Meyer, reputed as the king of medicinal herbs, has slow growth, long generation time, low seed production and complicated genome structure that hamper its study. Here, we unveil the genomic architecture of tetraploid P. ginseng by de novo genome assembly, representing 2.98 Gbp with 59 352 annotated genes. Resequencing data indicated that diploid Panax species diverged in association with global warming in Southern Asia, and two North American species evolved via two intercontinental migrations. Two whole genome duplications (WGD) occurred in the family Araliaceae (including Panax) after divergence with the Apiaceae, the more recent one contributing to the ability of P. ginseng to overwinter, enabling it to spread broadly through the Northern Hemisphere. Functional and evolutionary analyses suggest that production of pharmacologically important dammarane-type ginsenosides originated in Panax and are produced largely in shoot tissues and transported to roots; that newly evolved P. ginseng fatty acid desaturases increase freezing tolerance; and that unprecedented retention of chlorophyll a/b binding protein genes enables efficient photosynthesis under low light. A genome-scale metabolic network provides a holistic view of Panax ginsenoside biosynthesis. This study provides valuable resources for improving medicinal values of ginseng either through genomics-assisted breeding or metabolic engineering. |
| format |
Journal article |
| author |
Kim, Nam-Hoon Jayakodi, Murukarthick Lee, Sang-Choon Choi, Beom-Soon Jang, Woojong Lee, Junki Kim, Hyun Hee Waminal, Nomar E Lakshmanan, Meiyappan Nguyễn, Văn Bình Lee, Yun Sun Park, Hyun-Seung Koo, Hyun Jo Park, Jee Young Perumal, Sampath Joh, Ho Jun Lee, Hana Kim, Jinkyung Kim, In Seo Kim, Kyunghee Koduru, Lokanand Kang, Kyo Bin Sung, Sang Hyun Yu, Yeisoo Park, Daniel S Choi, Doil Seo, Eunyoung Kim, Seungill Kim, Young-Chang Hyun, Dong Yun Park, Youn-Il Kim, Changsoo Lee, Tae-Ho Kim, Hyun Uk Soh, Moon Soo Lee, Yi In, Jun Gyo Kim, Heui-Soo Kim, Yong-Min Yang, Deok-Chun Wing, Rod A Lee, Dong-Yup Paterson, Andrew H Yang, Tae-Jin |
| author_facet |
Kim, Nam-Hoon Jayakodi, Murukarthick Lee, Sang-Choon Choi, Beom-Soon Jang, Woojong Lee, Junki Kim, Hyun Hee Waminal, Nomar E Lakshmanan, Meiyappan Nguyễn, Văn Bình Lee, Yun Sun Park, Hyun-Seung Koo, Hyun Jo Park, Jee Young Perumal, Sampath Joh, Ho Jun Lee, Hana Kim, Jinkyung Kim, In Seo Kim, Kyunghee Koduru, Lokanand Kang, Kyo Bin Sung, Sang Hyun Yu, Yeisoo Park, Daniel S Choi, Doil Seo, Eunyoung Kim, Seungill Kim, Young-Chang Hyun, Dong Yun Park, Youn-Il Kim, Changsoo Lee, Tae-Ho Kim, Hyun Uk Soh, Moon Soo Lee, Yi In, Jun Gyo Kim, Heui-Soo Kim, Yong-Min Yang, Deok-Chun Wing, Rod A Lee, Dong-Yup Paterson, Andrew H Yang, Tae-Jin |
| author_sort |
Kim, Nam-Hoon |
| title |
Genome and evolution of the shade-requiring medicinal herb Panax ginseng |
| title_short |
Genome and evolution of the shade-requiring medicinal herb Panax ginseng |
| title_full |
Genome and evolution of the shade-requiring medicinal herb Panax ginseng |
| title_fullStr |
Genome and evolution of the shade-requiring medicinal herb Panax ginseng |
| title_full_unstemmed |
Genome and evolution of the shade-requiring medicinal herb Panax ginseng |
| title_sort |
genome and evolution of the shade-requiring medicinal herb panax ginseng |
| publishDate |
2022 |
| url |
http://scholar.dlu.edu.vn/handle/123456789/1313 |
| _version_ |
1768306003210665984 |