MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling
Mitsugumin 53 (MG53) negatively regulates skeletal myogenesis by targeting insulin receptor substrate 1 (IRS-1). Here, we show that MG53 is an ubiquitin E3 ligase that induces IRS-1 ubiquitination with the help of an E2-conjugating enzyme, UBE2H. Molecular manipulations that disrupt the E3-ligase...
Enregistré dans:
| Auteur principal: | |
|---|---|
| Format: | Journal article |
| Langue: | English |
| Publié: |
Springer
2022
|
| Sujets: | |
| Accès en ligne: | http://scholar.dlu.edu.vn/handle/123456789/1569 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| Thư viện lưu trữ: | Thư viện Trường Đại học Đà Lạt |
|---|