Chemical composition, anti-microbial, anti-inflammatory and cytotoxic activity of essential oils from Melicope pteleifolia (Champ. ex Benth.) T.G.Hartley leaves and stems collected in Lam Dong province
The essential oils extracted by hydrodistillation from the leaves and stems of M. pteleifolia collected in Bidoup-Nui Ba National Park, Lam Dong province, Vietnam were investigated for their chemical composition and bioactivity. 29 compounds were identified in the leaf oil (MPL), of which trans-α-be...
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2023
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oai:scholar.dlu.edu.vn:123456789-30372024-06-15T08:40:14Z Chemical composition, anti-microbial, anti-inflammatory and cytotoxic activity of essential oils from Melicope pteleifolia (Champ. ex Benth.) T.G.Hartley leaves and stems collected in Lam Dong province Trịnh, Thị Điệp Lương, Văn Dũng Phung, Van Trung Do, Thi Thao Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Vũ, Thị Bảo Ngọc Melicope pteleifolia essential oil GC/MS anti-microbial activity NO inhibition cytotoxicity The essential oils extracted by hydrodistillation from the leaves and stems of M. pteleifolia collected in Bidoup-Nui Ba National Park, Lam Dong province, Vietnam were investigated for their chemical composition and bioactivity. 29 compounds were identified in the leaf oil (MPL), of which trans-α-bergamotene (41.1%), followed by trans-γ-bisabolene (13.0%), linalool (7.6%), and β-atlantol (7.3%) were the most abundant. The stem oil (MPS) contained 21 identified constituents, mainly trans-α-bergamotene (63.7%), limonene (7.4%), and linalool (7.1%). MPL exhibited inhibitory effects on S. aureus, B. subtilis, and L. fermentum, while MPS significantly inhibited the growth of S. aureus, B. subtilis, E. coli, and C. albican and showed minimal inhibition against three other bacteria. MPL inhibited NO production in macrophage RAW 264.7 cells (IC50 19.86 ± 0.16 g/mL). Both MPL and MPS showed significant cytotoxic effects on all three tested cell lines SK-LU-1, MCF-7, and HepG2 with the IC50 values of 20.80 ± 1.42, 25.90 ± 1.47, and 23.42 ± 1.78 g/mL (for MPL) and 25.36 ± 2.41, 46.46 ± 3.13, and 47.41 ± 2.91 g/mL (for MPS), respectively. Their antifungal, anti-inflammatory, and cytotoxic activity were evaluated and reported for the first time. 28 4 205-211 2023-10-02T09:58:49Z 2023-10-02T09:58:49Z 2023 Research article Bài báo đăng trên tạp chí trong nước (có ISSN), bao gồm book chapter https://scholar.dlu.edu.vn/handle/123456789/3037 en Journal of Medicinal Materials 1869-4735 |
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Thư viện Trường Đại học Đà Lạt |
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Thư viện số |
| language |
English |
| topic |
Melicope pteleifolia essential oil GC/MS anti-microbial activity NO inhibition cytotoxicity |
| spellingShingle |
Melicope pteleifolia essential oil GC/MS anti-microbial activity NO inhibition cytotoxicity Trịnh, Thị Điệp Lương, Văn Dũng Phung, Van Trung Do, Thi Thao Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Vũ, Thị Bảo Ngọc Chemical composition, anti-microbial, anti-inflammatory and cytotoxic activity of essential oils from Melicope pteleifolia (Champ. ex Benth.) T.G.Hartley leaves and stems collected in Lam Dong province |
| description |
The essential oils extracted by hydrodistillation from the leaves and stems of M. pteleifolia collected in Bidoup-Nui Ba National Park, Lam Dong province, Vietnam were investigated for their chemical composition and bioactivity. 29 compounds were identified in the leaf oil (MPL), of which trans-α-bergamotene (41.1%), followed by trans-γ-bisabolene (13.0%), linalool (7.6%), and β-atlantol (7.3%) were the most abundant. The stem oil (MPS) contained 21 identified constituents, mainly trans-α-bergamotene (63.7%), limonene (7.4%), and linalool (7.1%). MPL exhibited inhibitory effects on S. aureus, B. subtilis, and L. fermentum, while MPS significantly inhibited the growth of S. aureus, B. subtilis, E. coli, and C. albican and showed minimal inhibition against three other bacteria. MPL inhibited NO production in macrophage RAW 264.7 cells (IC50 19.86 ± 0.16 g/mL). Both MPL and MPS showed significant cytotoxic effects on all three tested cell lines SK-LU-1, MCF-7, and HepG2 with the IC50 values of 20.80 ± 1.42, 25.90 ± 1.47, and 23.42 ± 1.78 g/mL (for MPL) and 25.36 ± 2.41, 46.46 ± 3.13, and 47.41 ± 2.91 g/mL (for MPS), respectively. Their antifungal, anti-inflammatory, and cytotoxic activity were evaluated and reported for the first time. |
| format |
Research article |
| author |
Trịnh, Thị Điệp Lương, Văn Dũng Phung, Van Trung Do, Thi Thao Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Vũ, Thị Bảo Ngọc |
| author_facet |
Trịnh, Thị Điệp Lương, Văn Dũng Phung, Van Trung Do, Thi Thao Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Vũ, Thị Bảo Ngọc |
| author_sort |
Trịnh, Thị Điệp |
| title |
Chemical composition, anti-microbial, anti-inflammatory and cytotoxic activity of essential oils from Melicope pteleifolia (Champ. ex Benth.) T.G.Hartley leaves and stems collected in Lam Dong province |
| title_short |
Chemical composition, anti-microbial, anti-inflammatory and cytotoxic activity of essential oils from Melicope pteleifolia (Champ. ex Benth.) T.G.Hartley leaves and stems collected in Lam Dong province |
| title_full |
Chemical composition, anti-microbial, anti-inflammatory and cytotoxic activity of essential oils from Melicope pteleifolia (Champ. ex Benth.) T.G.Hartley leaves and stems collected in Lam Dong province |
| title_fullStr |
Chemical composition, anti-microbial, anti-inflammatory and cytotoxic activity of essential oils from Melicope pteleifolia (Champ. ex Benth.) T.G.Hartley leaves and stems collected in Lam Dong province |
| title_full_unstemmed |
Chemical composition, anti-microbial, anti-inflammatory and cytotoxic activity of essential oils from Melicope pteleifolia (Champ. ex Benth.) T.G.Hartley leaves and stems collected in Lam Dong province |
| title_sort |
chemical composition, anti-microbial, anti-inflammatory and cytotoxic activity of essential oils from melicope pteleifolia (champ. ex benth.) t.g.hartley leaves and stems collected in lam dong province |
| publishDate |
2023 |
| url |
https://scholar.dlu.edu.vn/handle/123456789/3037 |
| _version_ |
1813142598852804608 |