Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam
This study was aimed to investigate the chemical composition and biological activities of leaf and stem essential oils of Zanthoxylum acanthopodium DC. from Vietnam. Their chemical composition was analyzed by GC/MS. Antimicrobial activities were evaluated by microdilution broth assay. Anti-inflammat...
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2024
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oai:scholar.dlu.edu.vn:123456789-32792024-01-18T02:26:24Z Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam Trịnh, Thị Điệp Lương, Văn Dũng Trung, Phung Van Hoai, Nguyen Thi Thao, Do Thi Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Ha, Trang Hanh Nhat Huỳnh, Thanh Trúc Zanthoxylum acanthopodium; antimicrobial activity; chemical composition; cytotoxicity; essential oil This study was aimed to investigate the chemical composition and biological activities of leaf and stem essential oils of Zanthoxylum acanthopodium DC. from Vietnam. Their chemical composition was analyzed by GC/MS. Antimicrobial activities were evaluated by microdilution broth assay. Anti-inflammatory activity was evaluated by the ability to inhibit nitric oxide production in macrophage cells. Cytotoxic activity was evaluated using the sulforhodamine B assay on three human cancer cell lines. Forty-four compounds were identified in the leaf oil, among which dehydroaromadendrane (23.4 %), (E)-carpacin (17.6 %), 2-tridecanone (12.2 %), and 9-methyl-2-decanone (11.8 %) were the most abundant. The stem oil contained fifty-five identified constituents, mainly γ-gurjunene (51.1 %) and butyl acetate (11.8 %). Both oils exhibited inhibitory effects on three bacterial strains, namely S. aureus, E. coli, P. aeruginosa and a fungal strain C. albican, while showed insignificant effects on B. subtilis, L. fermentum, and S. enterica. Both oils showed weak NO production inhibition in LPS-induced RAW264.7 cells, but exhibited potent cytotoxic activity against all three tested cell lines SK-LU-1, MCF-7, and HepG2 with the IC50 values ranging from 16.03±0.77 to 35.60±1.62 μg/mL. This is the first report on the antimicrobial, anti-inflammatory and cytotoxic activities of essential oils from the leaves and stems of Z. acanthopodium. 20 8 e202300649 2024-01-18T02:26:22Z 2024-01-18T02:26:22Z 2023-08 Research article Bài báo đăng trên tạp chí thuộc ISI, bao gồm book chapter https://scholar.dlu.edu.vn/handle/123456789/3279 10.1002/cbdv.202300649 37471031 en B2022-CT562-06 Chemistry & biodiversity #PLACEHOLDER_PARENT_METADATA_VALUE# |
| institution |
Thư viện Trường Đại học Đà Lạt |
| collection |
Thư viện số |
| language |
English |
| topic |
Zanthoxylum acanthopodium; antimicrobial activity; chemical composition; cytotoxicity; essential oil |
| spellingShingle |
Zanthoxylum acanthopodium; antimicrobial activity; chemical composition; cytotoxicity; essential oil Trịnh, Thị Điệp Lương, Văn Dũng Trung, Phung Van Hoai, Nguyen Thi Thao, Do Thi Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Ha, Trang Hanh Nhat Huỳnh, Thanh Trúc Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam |
| description |
This study was aimed to investigate the chemical composition and biological activities of leaf and stem essential oils of Zanthoxylum acanthopodium DC. from Vietnam. Their chemical composition was analyzed by GC/MS. Antimicrobial activities were evaluated by microdilution broth assay. Anti-inflammatory activity was evaluated by the ability to inhibit nitric oxide production in macrophage cells. Cytotoxic activity was evaluated using the sulforhodamine B assay on three human cancer cell lines. Forty-four compounds were identified in the leaf oil, among which dehydroaromadendrane (23.4 %), (E)-carpacin (17.6 %), 2-tridecanone (12.2 %), and 9-methyl-2-decanone (11.8 %) were the most abundant. The stem oil contained fifty-five identified constituents, mainly γ-gurjunene (51.1 %) and butyl acetate (11.8 %). Both oils exhibited inhibitory effects on three bacterial strains, namely S. aureus, E. coli, P. aeruginosa and a fungal strain C. albican, while showed insignificant effects on B. subtilis, L. fermentum, and S. enterica. Both oils showed weak NO production inhibition in LPS-induced RAW264.7 cells, but exhibited potent cytotoxic activity against all three tested cell lines SK-LU-1, MCF-7, and HepG2 with the IC50 values ranging from 16.03±0.77 to 35.60±1.62 μg/mL. This is the first report on the antimicrobial, anti-inflammatory and cytotoxic activities of essential oils from the leaves and stems of Z. acanthopodium. |
| format |
Research article |
| author |
Trịnh, Thị Điệp Lương, Văn Dũng Trung, Phung Van Hoai, Nguyen Thi Thao, Do Thi Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Ha, Trang Hanh Nhat Huỳnh, Thanh Trúc |
| author_facet |
Trịnh, Thị Điệp Lương, Văn Dũng Trung, Phung Van Hoai, Nguyen Thi Thao, Do Thi Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Ha, Trang Hanh Nhat Huỳnh, Thanh Trúc |
| author_sort |
Trịnh, Thị Điệp |
| title |
Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam |
| title_short |
Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam |
| title_full |
Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam |
| title_fullStr |
Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam |
| title_full_unstemmed |
Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam |
| title_sort |
chemical composition, antimicrobial, nitric oxide inhibition and cytotoxic activity of essential oils from zanthoxylum acanthopodium dc. leaves and stems from vietnam |
| publishDate |
2024 |
| url |
https://scholar.dlu.edu.vn/handle/123456789/3279 |
| _version_ |
1798256973530005504 |