Essential oils from Acronychia pedunculata (L.) Miq. in Vietnam: chemical composition, antimicrobial, cytotoxicity and nitric oxide inhibition activities
The chemical composition, antimicrobial, cytotoxic and anti-inflammatory activities of essential oils from different parts of Acronychia pedunculata, a medicinal plant native to Central Highlands of Vietnam, were investigated. Their chemical constituents were determined using GC-MS. The antimicrobia...
Đã lưu trong:
| Những tác giả chính: | , , , , , , |
|---|---|
| Định dạng: | Research article |
| Ngôn ngữ: | English |
| Được phát hành: |
Taylor & Francis
2024
|
| Những chủ đề: | |
| Truy cập trực tuyến: | https://scholar.dlu.edu.vn/handle/123456789/3280 https://doi.org/10.1080/0972060X.2023.2287595 |
| Các nhãn: |
Thêm thẻ
Không có thẻ, Là người đầu tiên thẻ bản ghi này!
|
| Thư viện lưu trữ: | Thư viện Trường Đại học Đà Lạt |
|---|
| id |
oai:scholar.dlu.edu.vn:123456789-3280 |
|---|---|
| record_format |
dspace |
| spelling |
oai:scholar.dlu.edu.vn:123456789-32802024-01-18T03:10:17Z Essential oils from Acronychia pedunculata (L.) Miq. in Vietnam: chemical composition, antimicrobial, cytotoxicity and nitric oxide inhibition activities Trịnh, Thị Điệp Lương, Văn Dũng Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Phung Van Trung, Nguyen Thi Hoai, Do Thi Thao Acronychia pedunculata Cytotoxicity essential oil anti-microbial activity NO inhibition The chemical composition, antimicrobial, cytotoxic and anti-inflammatory activities of essential oils from different parts of Acronychia pedunculata, a medicinal plant native to Central Highlands of Vietnam, were investigated. Their chemical constituents were determined using GC-MS. The antimicrobial properties were assessed using a microdilution broth method, while the anti-inflammatory properties were measured based on their capacity to inhibit NO production in macrophage cells. Their cytotoxicity was tested using the sulforhodamine B assay on three human cancer cell lines. The GC-MS analysis revealed the presence mainly of caryophyllene oxide (35.3%) and spathulenol (31.9%) in the stem essential oil, caryophyllene oxide (51.3%), and linalool (21.0%) in the leaf essential oil, and α-pinene (21.4%), (E)-β-ocimene (16.5%), linalool (12.5%), and β-caryophyllene (13.0%) in the fruit essential oil. All three essential oils inhibited the growth of various bacteria and fungi, reduced NO production in LPS-induced RAW264.7 cells, and exhibited cytotoxicity against all three tested cancer cell lines. Notably, the fruit essential oil showed the most potent cytotoxicity among the essential oils, with IC50 values of 5.47 ± 0.21, 7.95 ± 0.35, and 9.22 ± 0.52 g/mL against SK-LU-1, MCF-7, and HepG2 cells, respectively. It also had a strong anti-inflammatory effect that was comparable to that of dexamethasone, with an IC50 value of NO production inhibition of 14.62 ± 0.62 mg/mL. These results suggest the potential of the essential oils from this plant to provide leads for the development of anti-inflammatory and anti-cancer agents. 26 6 1460-1472 2024-01-18T03:10:13Z 2024-01-18T03:10:13Z 2023 Research article Bài báo đăng trên tạp chí thuộc ISI, bao gồm book chapter https://scholar.dlu.edu.vn/handle/123456789/3280 10.1080/0972060X.2023.2287595 https://doi.org/10.1080/0972060X.2023.2287595 en B2022-CT562-06 Journal of Essential Oil Bearing Plants #PLACEHOLDER_PARENT_METADATA_VALUE# Taylor & Francis |
| institution |
Thư viện Trường Đại học Đà Lạt |
| collection |
Thư viện số |
| language |
English |
| topic |
Acronychia pedunculata Cytotoxicity essential oil anti-microbial activity NO inhibition |
| spellingShingle |
Acronychia pedunculata Cytotoxicity essential oil anti-microbial activity NO inhibition Trịnh, Thị Điệp Lương, Văn Dũng Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Phung Van Trung, Nguyen Thi Hoai, Do Thi Thao Essential oils from Acronychia pedunculata (L.) Miq. in Vietnam: chemical composition, antimicrobial, cytotoxicity and nitric oxide inhibition activities |
| description |
The chemical composition, antimicrobial, cytotoxic and anti-inflammatory activities of essential oils from different parts of Acronychia pedunculata, a medicinal plant native to Central Highlands of Vietnam, were investigated. Their chemical constituents were determined using GC-MS. The antimicrobial properties were assessed using a microdilution broth method, while the anti-inflammatory properties were measured based on their capacity to inhibit NO production in macrophage cells. Their cytotoxicity was tested using the sulforhodamine B assay on three human cancer cell lines. The GC-MS analysis revealed the presence mainly of caryophyllene oxide (35.3%) and spathulenol (31.9%) in the stem essential oil, caryophyllene oxide (51.3%), and linalool (21.0%) in the leaf essential oil, and α-pinene (21.4%), (E)-β-ocimene (16.5%), linalool (12.5%), and β-caryophyllene (13.0%) in the fruit essential oil. All three essential oils inhibited the growth of various bacteria and fungi, reduced NO production in LPS-induced RAW264.7 cells, and exhibited cytotoxicity against all three tested cancer cell lines. Notably, the fruit essential oil showed the most potent cytotoxicity among the essential oils, with IC50 values of 5.47 ± 0.21, 7.95 ± 0.35, and 9.22 ± 0.52 g/mL against SK-LU-1, MCF-7, and HepG2 cells, respectively. It also had a strong anti-inflammatory effect that was comparable to that of dexamethasone, with an IC50 value of NO production inhibition of 14.62 ± 0.62 mg/mL. These results suggest the potential of the essential oils from this plant to provide leads for the development of anti-inflammatory and anti-cancer agents. |
| format |
Research article |
| author |
Trịnh, Thị Điệp Lương, Văn Dũng Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Phung Van Trung, Nguyen Thi Hoai, Do Thi Thao |
| author_facet |
Trịnh, Thị Điệp Lương, Văn Dũng Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Phung Van Trung, Nguyen Thi Hoai, Do Thi Thao |
| author_sort |
Trịnh, Thị Điệp |
| title |
Essential oils from Acronychia pedunculata (L.) Miq. in Vietnam: chemical composition, antimicrobial, cytotoxicity and nitric oxide inhibition activities |
| title_short |
Essential oils from Acronychia pedunculata (L.) Miq. in Vietnam: chemical composition, antimicrobial, cytotoxicity and nitric oxide inhibition activities |
| title_full |
Essential oils from Acronychia pedunculata (L.) Miq. in Vietnam: chemical composition, antimicrobial, cytotoxicity and nitric oxide inhibition activities |
| title_fullStr |
Essential oils from Acronychia pedunculata (L.) Miq. in Vietnam: chemical composition, antimicrobial, cytotoxicity and nitric oxide inhibition activities |
| title_full_unstemmed |
Essential oils from Acronychia pedunculata (L.) Miq. in Vietnam: chemical composition, antimicrobial, cytotoxicity and nitric oxide inhibition activities |
| title_sort |
essential oils from acronychia pedunculata (l.) miq. in vietnam: chemical composition, antimicrobial, cytotoxicity and nitric oxide inhibition activities |
| publisher |
Taylor & Francis |
| publishDate |
2024 |
| url |
https://scholar.dlu.edu.vn/handle/123456789/3280 https://doi.org/10.1080/0972060X.2023.2287595 |
| _version_ |
1798256974014447616 |