Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province
Essential oils extracted by hydrodistillation from fruits, leaves, and stems of Z. myriacanthum collected in Bidoup-Nui Ba National Park, Lam Dong province, Vietnam were investigated for their chemical composition and bioactivity. 51 compounds were identified in the fruit oil (ZMFR), of which p-cyme...
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2024
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oai:scholar.dlu.edu.vn:123456789-32812024-01-18T03:28:12Z Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province Trịnh, Thị Điệp Lương, Văn Dũng Phung Van Trung, Do Thi Thao, Nguyen Thi Hoai Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Vũ, Thị Bảo Ngọc Zanthoxylum myriacanthum essential oil GC/MS cytotoxicity anti-inflammatory activity Essential oils extracted by hydrodistillation from fruits, leaves, and stems of Z. myriacanthum collected in Bidoup-Nui Ba National Park, Lam Dong province, Vietnam were investigated for their chemical composition and bioactivity. 51 compounds were identified in the fruit oil (ZMFR), of which p-cymen-8-ol (24.9%) and β-pinene (24.3%) were the most abundant. The leaf oil (ZML) contained 32 identified constituents, mainly ρ-methyl-acetophenone (29.9%), α-terpineol (17.0%), ar-curcumene (9.5%), (E)-carpacin (7.7%), 2-undecanone (6.6%) and 2-tridecanone (5.9%). The stem oil (ZMS) consisted of 23 compounds, the major ones being ar-curcumene (44.6%), terpinen-4-ol (13.2%), (1R,2R,4R)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexane-1,2-diol (8.8%) and α-terpineol (8.4%). ZMFR exhibited moderate NO production inhibition in macrophage RAW 264.7 cells with an IC50 value of 42.35 ± 2.63 g/mL. ZMFR and ZML showed moderate cytotoxic effects on SK-LU-1, MCF-7, and HepG2 cancer cell lines with the IC50 values ranging from 50.97 ± 4.07 to 93.78 ± 3.67g/mL. ZMS was cytotoxic against HepG2 (IC50 = 69.84 ± 4.71 g/mL) and MCF-7 (IC50 = 89.28 ± 5.50 g/mL), and showed minimal effect on SK-LU-1. The anti-inflammatory and cytotoxic activities of Z. myriacanthum essential oils were evaluated and reported for the first time. 28 6 343-351 2024-01-18T03:28:09Z 2024-01-18T03:28:09Z 2023 Research article Bài báo đăng trên tạp chí trong nước (có ISSN), bao gồm book chapter https://scholar.dlu.edu.vn/handle/123456789/3281 en B2022-CT562-06 Journal of Medicinal Materials #PLACEHOLDER_PARENT_METADATA_VALUE# |
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English |
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Zanthoxylum myriacanthum essential oil GC/MS cytotoxicity anti-inflammatory activity |
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Zanthoxylum myriacanthum essential oil GC/MS cytotoxicity anti-inflammatory activity Trịnh, Thị Điệp Lương, Văn Dũng Phung Van Trung, Do Thi Thao, Nguyen Thi Hoai Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Vũ, Thị Bảo Ngọc Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province |
description |
Essential oils extracted by hydrodistillation from fruits, leaves, and stems of Z. myriacanthum collected in Bidoup-Nui Ba National Park, Lam Dong province, Vietnam were investigated for their chemical composition and bioactivity. 51 compounds were identified in the fruit oil (ZMFR), of which p-cymen-8-ol (24.9%) and β-pinene (24.3%) were the most abundant. The leaf oil (ZML) contained 32 identified constituents, mainly ρ-methyl-acetophenone (29.9%), α-terpineol (17.0%), ar-curcumene (9.5%), (E)-carpacin (7.7%), 2-undecanone (6.6%) and 2-tridecanone (5.9%). The stem oil (ZMS) consisted of 23 compounds, the major ones being ar-curcumene (44.6%), terpinen-4-ol (13.2%), (1R,2R,4R)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexane-1,2-diol (8.8%) and α-terpineol (8.4%). ZMFR exhibited moderate NO production inhibition in macrophage RAW 264.7 cells with an IC50 value of 42.35 ± 2.63 g/mL. ZMFR and ZML showed moderate cytotoxic effects on SK-LU-1, MCF-7, and HepG2 cancer cell lines with the IC50 values ranging from 50.97 ± 4.07 to 93.78 ± 3.67g/mL. ZMS was cytotoxic against HepG2 (IC50 = 69.84 ± 4.71 g/mL) and MCF-7 (IC50 = 89.28 ± 5.50 g/mL), and showed minimal effect on SK-LU-1. The anti-inflammatory and cytotoxic activities of Z. myriacanthum essential oils were evaluated and reported for the first time. |
format |
Research article |
author |
Trịnh, Thị Điệp Lương, Văn Dũng Phung Van Trung, Do Thi Thao, Nguyen Thi Hoai Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Vũ, Thị Bảo Ngọc |
author_facet |
Trịnh, Thị Điệp Lương, Văn Dũng Phung Van Trung, Do Thi Thao, Nguyen Thi Hoai Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Vũ, Thị Bảo Ngọc |
author_sort |
Trịnh, Thị Điệp |
title |
Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province |
title_short |
Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province |
title_full |
Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province |
title_fullStr |
Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province |
title_full_unstemmed |
Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province |
title_sort |
chemical composition, anti-inflammatory and cytotoxic activities of essential oils from zanthoxylum myriacanthum wall. ex hook. f. fruits, leaves and stems collected in lam dong province |
publishDate |
2024 |
url |
https://scholar.dlu.edu.vn/handle/123456789/3281 |
_version_ |
1798256974342651904 |