Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province

Essential oils extracted by hydrodistillation from fruits, leaves, and stems of Z. myriacanthum collected in Bidoup-Nui Ba National Park, Lam Dong province, Vietnam were investigated for their chemical composition and bioactivity. 51 compounds were identified in the fruit oil (ZMFR), of which p-cyme...

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Những tác giả chính:	Trịnh, Thị Điệp, Lương, Văn Dũng, Phung Van Trung, Do Thi Thao, Nguyen Thi Hoai, Nguyễn, Thị Tố Uyên, Trần, Thị Hoài Linh, Huỳnh, Thanh Trúc, Lê, Thị Thanh Trân, Vũ, Thị Bảo Ngọc
Định dạng:	Research article
Ngôn ngữ:	English
Được phát hành:	2024
Những chủ đề:	Zanthoxylum myriacanthum essential oil GC/MS cytotoxicity anti-inflammatory activity
Truy cập trực tuyến:	https://scholar.dlu.edu.vn/handle/123456789/3281
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spelling	oai:scholar.dlu.edu.vn:123456789-32812024-01-18T03:28:12Z Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province Trịnh, Thị Điệp Lương, Văn Dũng Phung Van Trung, Do Thi Thao, Nguyen Thi Hoai Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Vũ, Thị Bảo Ngọc Zanthoxylum myriacanthum essential oil GC/MS cytotoxicity anti-inflammatory activity Essential oils extracted by hydrodistillation from fruits, leaves, and stems of Z. myriacanthum collected in Bidoup-Nui Ba National Park, Lam Dong province, Vietnam were investigated for their chemical composition and bioactivity. 51 compounds were identified in the fruit oil (ZMFR), of which p-cymen-8-ol (24.9%) and β-pinene (24.3%) were the most abundant. The leaf oil (ZML) contained 32 identified constituents, mainly ρ-methyl-acetophenone (29.9%), α-terpineol (17.0%), ar-curcumene (9.5%), (E)-carpacin (7.7%), 2-undecanone (6.6%) and 2-tridecanone (5.9%). The stem oil (ZMS) consisted of 23 compounds, the major ones being ar-curcumene (44.6%), terpinen-4-ol (13.2%), (1R,2R,4R)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexane-1,2-diol (8.8%) and α-terpineol (8.4%). ZMFR exhibited moderate NO production inhibition in macrophage RAW 264.7 cells with an IC50 value of 42.35 ± 2.63 g/mL. ZMFR and ZML showed moderate cytotoxic effects on SK-LU-1, MCF-7, and HepG2 cancer cell lines with the IC50 values ranging from 50.97 ± 4.07 to 93.78 ± 3.67g/mL. ZMS was cytotoxic against HepG2 (IC50 = 69.84 ± 4.71 g/mL) and MCF-7 (IC50 = 89.28 ± 5.50 g/mL), and showed minimal effect on SK-LU-1. The anti-inflammatory and cytotoxic activities of Z. myriacanthum essential oils were evaluated and reported for the first time. 28 6 343-351 2024-01-18T03:28:09Z 2024-01-18T03:28:09Z 2023 Research article Bài báo đăng trên tạp chí trong nước (có ISSN), bao gồm book chapter https://scholar.dlu.edu.vn/handle/123456789/3281 en B2022-CT562-06 Journal of Medicinal Materials #PLACEHOLDER_PARENT_METADATA_VALUE#
institution	Thư viện Trường Đại học Đà Lạt
collection	Thư viện số
language	English
topic	Zanthoxylum myriacanthum essential oil GC/MS cytotoxicity anti-inflammatory activity
spellingShingle	Zanthoxylum myriacanthum essential oil GC/MS cytotoxicity anti-inflammatory activity Trịnh, Thị Điệp Lương, Văn Dũng Phung Van Trung, Do Thi Thao, Nguyen Thi Hoai Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Vũ, Thị Bảo Ngọc Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province
description	Essential oils extracted by hydrodistillation from fruits, leaves, and stems of Z. myriacanthum collected in Bidoup-Nui Ba National Park, Lam Dong province, Vietnam were investigated for their chemical composition and bioactivity. 51 compounds were identified in the fruit oil (ZMFR), of which p-cymen-8-ol (24.9%) and β-pinene (24.3%) were the most abundant. The leaf oil (ZML) contained 32 identified constituents, mainly ρ-methyl-acetophenone (29.9%), α-terpineol (17.0%), ar-curcumene (9.5%), (E)-carpacin (7.7%), 2-undecanone (6.6%) and 2-tridecanone (5.9%). The stem oil (ZMS) consisted of 23 compounds, the major ones being ar-curcumene (44.6%), terpinen-4-ol (13.2%), (1R,2R,4R)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexane-1,2-diol (8.8%) and α-terpineol (8.4%). ZMFR exhibited moderate NO production inhibition in macrophage RAW 264.7 cells with an IC50 value of 42.35 ± 2.63 g/mL. ZMFR and ZML showed moderate cytotoxic effects on SK-LU-1, MCF-7, and HepG2 cancer cell lines with the IC50 values ranging from 50.97 ± 4.07 to 93.78 ± 3.67g/mL. ZMS was cytotoxic against HepG2 (IC50 = 69.84 ± 4.71 g/mL) and MCF-7 (IC50 = 89.28 ± 5.50 g/mL), and showed minimal effect on SK-LU-1. The anti-inflammatory and cytotoxic activities of Z. myriacanthum essential oils were evaluated and reported for the first time.
format	Research article
author	Trịnh, Thị Điệp Lương, Văn Dũng Phung Van Trung, Do Thi Thao, Nguyen Thi Hoai Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Vũ, Thị Bảo Ngọc
author_facet	Trịnh, Thị Điệp Lương, Văn Dũng Phung Van Trung, Do Thi Thao, Nguyen Thi Hoai Nguyễn, Thị Tố Uyên Trần, Thị Hoài Linh Huỳnh, Thanh Trúc Lê, Thị Thanh Trân Vũ, Thị Bảo Ngọc
author_sort	Trịnh, Thị Điệp
title	Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province
title_short	Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province
title_full	Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province
title_fullStr	Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province
title_full_unstemmed	Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province
title_sort	chemical composition, anti-inflammatory and cytotoxic activities of essential oils from zanthoxylum myriacanthum wall. ex hook. f. fruits, leaves and stems collected in lam dong province
publishDate	2024
url	https://scholar.dlu.edu.vn/handle/123456789/3281
_version_	1798256974342651904

Chemical composition, anti-inflammatory and cytotoxic activities of essential oils from Zanthoxylum myriacanthum Wall. ex Hook. f. fruits, leaves and stems collected in Lam Dong province

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