Kinesins and Cancer
This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting the importance of kinesins, summarising current knowledge and...
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| Định dạng: | Sách |
| Ngôn ngữ: | English |
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Springer
2015
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| Truy cập trực tuyến: | https://scholar.dlu.edu.vn/thuvienso/handle/DLU123456789/57832 |
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oai:scholar.dlu.edu.vn:DLU123456789-578322023-11-11T05:51:18Z Kinesins and Cancer Kozielski, Frank Biochemistry Life Sciences Science Development Antineoplastic agents Kinesin This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting the importance of kinesins, summarising current knowledge and how they are shown to be crucial for mitosis. Chapters go on to explore how this family of proteins are emerging as a novel target for chemotherapeutic intervention and drug development. Readers will learn how kinesins travel along microtubules to fulfill their many roles in intracellular transport or cell division. Several compounds that inhibit two mitotic kinesins (called Eg5 and CENP-E) have entered Phase I and II clinical trials and are explored in these chapters. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the repertoire of kinesin-based drug targets may expand in the future. 2015-08-31T01:33:42Z 2015-08-31T01:33:42Z 2015 Book 978-94-017-9732-0 https://scholar.dlu.edu.vn/thuvienso/handle/DLU123456789/57832 en application/pdf Springer |
| institution |
Thư viện Trường Đại học Đà Lạt |
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Thư viện số |
| language |
English |
| topic |
Biochemistry Life Sciences Science Development Antineoplastic agents Kinesin |
| spellingShingle |
Biochemistry Life Sciences Science Development Antineoplastic agents Kinesin Kozielski, Frank Kinesins and Cancer |
| description |
This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting the importance of kinesins, summarising current knowledge and how they are shown to be crucial for mitosis. Chapters go on to explore how this family of proteins are emerging as a novel target for chemotherapeutic intervention and drug development.
Readers will learn how kinesins travel along microtubules to fulfill their many roles in intracellular transport or cell division. Several compounds that inhibit two mitotic kinesins (called Eg5 and CENP-E) have entered Phase I and II clinical trials and are explored in these chapters. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the repertoire of kinesin-based drug targets may expand in the future. |
| format |
Book |
| author |
Kozielski, Frank |
| author_facet |
Kozielski, Frank |
| author_sort |
Kozielski, Frank |
| title |
Kinesins and Cancer |
| title_short |
Kinesins and Cancer |
| title_full |
Kinesins and Cancer |
| title_fullStr |
Kinesins and Cancer |
| title_full_unstemmed |
Kinesins and Cancer |
| title_sort |
kinesins and cancer |
| publisher |
Springer |
| publishDate |
2015 |
| url |
https://scholar.dlu.edu.vn/thuvienso/handle/DLU123456789/57832 |
| _version_ |
1782534502090801152 |