Particle Toxicology
Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the...
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CRC Press
2009
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| Truy cập trực tuyến: | https://scholar.dlu.edu.vn/thuvienso/handle/DLU123456789/958 |
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Thư viện Trường Đại học Đà Lạt |
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English |
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Environmental Sciences |
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Environmental Sciences Donaldson, Ken Borm, Paul Particle Toxicology |
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Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences.
Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of "dose" dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research.
Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop new concepts to understanding particle actions, measurement, testing, and pathogenic exposure to fine and ultrafine particles. |
| format |
Book |
| author |
Donaldson, Ken Borm, Paul |
| author_facet |
Donaldson, Ken Borm, Paul |
| author_sort |
Donaldson, Ken |
| title |
Particle Toxicology |
| title_short |
Particle Toxicology |
| title_full |
Particle Toxicology |
| title_fullStr |
Particle Toxicology |
| title_full_unstemmed |
Particle Toxicology |
| title_sort |
particle toxicology |
| publisher |
CRC Press |
| publishDate |
2009 |
| url |
https://scholar.dlu.edu.vn/thuvienso/handle/DLU123456789/958 |
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1819812013305495552 |
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oai:scholar.dlu.edu.vn:DLU123456789-9582009-10-12T03:35:18Z Particle Toxicology Donaldson, Ken Borm, Paul Environmental Sciences Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences. Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of "dose" dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research. Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop new concepts to understanding particle actions, measurement, testing, and pathogenic exposure to fine and ultrafine particles. An Introduction to Particle Toxicology: From Coal Mining to Nanotechnology, P. J. A. Borm and K. Donaldson Mineralogy and Structure of Pathogenic Particles, T. Jones and K. BéruBé Particle Dosimetry: Deposition and Clearance from the Respiratory Tract and Translocation towards Extra-Pulmonary Sites, W. G. Kreyling, G. Oberdorster, W. Möller, and M. Semmler-Behnke Particulate Air Pollutants and Small Airway Remodeling, A. Churg Particle-Mediated Extracellular Oxidative Stress in the Lung, F. J. Kelly and I. S. Mudway Particles and Cellular Oxidative and Nitrosative Stress, D. W. Porter, S. S. Leonard, and V. Castranova Interaction of Particles with Membranes, B. Rothen-Rutishauser, S. Schürch, and P. Gehr Particle-Associated Metals and Oxidative Stress in Signaling, J. M. Samet and A. J. Ghio Proinflammatory Effects of Particles on Macrophages and Epithelial Cells, V. Stone, P. G. Barlow, G. R. Hutchinson, and D. M. Brown Cell-Signaling Pathways Elicited by Particulates, J. E. Levis and B. T. Mossman Particle-Associated Organics and Proinflammatory Signaling, F. Marano, S. Boland, and A. Baeza-Squiban The Asbestos Model of Interstitial Pulmonary Fibrosis: TNF-a and TGF-b1 as Mediators of Asbestos-Induced Lung Fibrogenesis, D. E. Sullivan and A. R. Brody Effects of Particles on the Immune System, I. Gilmour, T. Stevens, and R. K. Saxena Effects of Particles on the Cardiovascular System, N. Mills, D. E. Newby, W. MacNee, and K. Donaldson Susceptibility to Particle Effects, S. R. Kleeberger and R. Howden Genotoxic Effects of Particles, R. P. F. Schins and T. K. Hei Approaches to the Toxicological Testing of Particles, K. Donaldson, S. Faux, P. Borm, and V. Stone Models for Testing the Pulmonary Toxicity of Particles: Lung Bioassay Screening Studies in Male Rats with a New Formulation of TiO2 Particulates, D. B. Warheit, K. L. Reed, and C. M. Sayes Air Pollution and Human Brain Pathology: A Role for Air Pollutants in the Pathogensis of Alzheimer's Disease, L. Calderón-Garcidueñas and W. Reed Biologically-Based Lung Dosimetry and Exposure-Dose-Response Models for Poorly Soluble Inhaled Particles, L. Tran and E. Kuempel Nanoparticles in Medicine, P. J. A. Borm and D. Muller-Schulte The Toxicology of Inhaled Particles: Summing Up an Emerging Conceptual Framework, K. Donaldson, L. Tran, and P. Borm Index 2009-10-12T03:35:18Z 2009-10-12T03:35:18Z 2006 Book 084935092 https://scholar.dlu.edu.vn/thuvienso/handle/DLU123456789/958 en application/octet-stream CRC Press |