MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling
Mitsugumin 53 (MG53) negatively regulates skeletal myogenesis by targeting insulin receptor substrate 1 (IRS-1). Here, we show that MG53 is an ubiquitin E3 ligase that induces IRS-1 ubiquitination with the help of an E2-conjugating enzyme, UBE2H. Molecular manipulations that disrupt the E3-ligase...
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
Springer
2022
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| 主題: | |
| 在線閱讀: | http://scholar.dlu.edu.vn/handle/123456789/1569 |
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| Thư viện lưu trữ: | Thư viện Trường Đại học Đà Lạt |
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