Citrus limon peel powder reduces intestinal barrier defects and inflammation in a colitic murine experimental model
This study examines the ameliorative effects of lemon (Citrus limon) peel (LP) powder on intestinal inflammation and barrier defects in dextran sulfate sodium (DSS)-induced colitic mice. The whole LP powder was fractionated into methanol (MetOH) extract and its extraction residue (MetOH residue),...
Đã lưu trong:
| Những tác giả chính: | , , , |
|---|---|
| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
2022
|
| Những chủ đề: | |
| Truy cập trực tuyến: | https://scholar.dlu.edu.vn/handle/123456789/818 |
| Các nhãn: |
Thêm thẻ
Không có thẻ, Là người đầu tiên thẻ bản ghi này!
|
| Thư viện lưu trữ: | Thư viện Trường Đại học Đà Lạt |
|---|
| Tóm tắt: | This study examines the ameliorative effects of lemon (Citrus limon) peel (LP) powder on
intestinal inflammation and barrier defects in dextran sulfate sodium (DSS)-induced colitic mice. The
whole LP powder was fractionated into methanol (MetOH) extract and its extraction residue (MetOH
residue), which were rich in polyphenolic compounds and dietary fibers, respectively. Mice were fed
diets containing whole LP powder, MetOH extract, and MetOH residue for 16 d. DSS administration
for 9 d induced bodyweight loss, reduced colon length, reduced the colonic expression of tight
junction proteins including zonula occludens-1 and -2, and claudin-3 and -7, and upregulated colonic
mRNA expression of interleukin 6, chemokine (C-X-C motif) ligand 2, and C-C motif chemokine
ligand 2. Feeding LP powder restored these abnormalities, and the MetOH residue, but not MetOH
extract, also showed similar restorations. Feeding LP powder and MetOH residue increased fecal
concentrations of acetate and n-butyrate. Taken together, LP powder reduced intestinal damage
through the protection of tight junction barriers and suppressed an inflammatory reaction in colitic
mice. These results suggest that acetate and n-butyrate produced from the microbial metabolism of
dietary fibers in LP powder contributed to reducing colitis. |
|---|