Citrus limon peel powder reduces intestinal barrier defects and inflammation in a colitic murine experimental model
This study examines the ameliorative effects of lemon (Citrus limon) peel (LP) powder on intestinal inflammation and barrier defects in dextran sulfate sodium (DSS)-induced colitic mice. The whole LP powder was fractionated into methanol (MetOH) extract and its extraction residue (MetOH residue),...
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| Định dạng: | Journal article |
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2022
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oai:scholar.dlu.edu.vn:123456789-8182023-12-21T15:13:04Z Citrus limon peel powder reduces intestinal barrier defects and inflammation in a colitic murine experimental model Nguyễn, Thị Thanh Tịnh Gertrude Cynthia Sitolo Yoshinari Yamamoto Takuya Suzuki colitis; dietary fiber; lemon peel; inflammatory cytokine; tight junction This study examines the ameliorative effects of lemon (Citrus limon) peel (LP) powder on intestinal inflammation and barrier defects in dextran sulfate sodium (DSS)-induced colitic mice. The whole LP powder was fractionated into methanol (MetOH) extract and its extraction residue (MetOH residue), which were rich in polyphenolic compounds and dietary fibers, respectively. Mice were fed diets containing whole LP powder, MetOH extract, and MetOH residue for 16 d. DSS administration for 9 d induced bodyweight loss, reduced colon length, reduced the colonic expression of tight junction proteins including zonula occludens-1 and -2, and claudin-3 and -7, and upregulated colonic mRNA expression of interleukin 6, chemokine (C-X-C motif) ligand 2, and C-C motif chemokine ligand 2. Feeding LP powder restored these abnormalities, and the MetOH residue, but not MetOH extract, also showed similar restorations. Feeding LP powder and MetOH residue increased fecal concentrations of acetate and n-butyrate. Taken together, LP powder reduced intestinal damage through the protection of tight junction barriers and suppressed an inflammatory reaction in colitic mice. These results suggest that acetate and n-butyrate produced from the microbial metabolism of dietary fibers in LP powder contributed to reducing colitis. 10(2) 240 1-15 2022-08-16T09:03:24Z 2022-08-16T09:03:24Z 2021-01-25 Journal article Bài báo đăng trên tạp chí thuộc ISI, bao gồm book chapter https://scholar.dlu.edu.vn/handle/123456789/818 10.3390/foods10020240 en Foods 2304-8158 |
| institution |
Thư viện Trường Đại học Đà Lạt |
| collection |
Thư viện số |
| language |
English |
| topic |
colitis; dietary fiber; lemon peel; inflammatory cytokine; tight junction |
| spellingShingle |
colitis; dietary fiber; lemon peel; inflammatory cytokine; tight junction Nguyễn, Thị Thanh Tịnh Gertrude Cynthia Sitolo Yoshinari Yamamoto Takuya Suzuki Citrus limon peel powder reduces intestinal barrier defects and inflammation in a colitic murine experimental model |
| description |
This study examines the ameliorative effects of lemon (Citrus limon) peel (LP) powder on
intestinal inflammation and barrier defects in dextran sulfate sodium (DSS)-induced colitic mice. The
whole LP powder was fractionated into methanol (MetOH) extract and its extraction residue (MetOH
residue), which were rich in polyphenolic compounds and dietary fibers, respectively. Mice were fed
diets containing whole LP powder, MetOH extract, and MetOH residue for 16 d. DSS administration
for 9 d induced bodyweight loss, reduced colon length, reduced the colonic expression of tight
junction proteins including zonula occludens-1 and -2, and claudin-3 and -7, and upregulated colonic
mRNA expression of interleukin 6, chemokine (C-X-C motif) ligand 2, and C-C motif chemokine
ligand 2. Feeding LP powder restored these abnormalities, and the MetOH residue, but not MetOH
extract, also showed similar restorations. Feeding LP powder and MetOH residue increased fecal
concentrations of acetate and n-butyrate. Taken together, LP powder reduced intestinal damage
through the protection of tight junction barriers and suppressed an inflammatory reaction in colitic
mice. These results suggest that acetate and n-butyrate produced from the microbial metabolism of
dietary fibers in LP powder contributed to reducing colitis. |
| format |
Journal article |
| author |
Nguyễn, Thị Thanh Tịnh Gertrude Cynthia Sitolo Yoshinari Yamamoto Takuya Suzuki |
| author_facet |
Nguyễn, Thị Thanh Tịnh Gertrude Cynthia Sitolo Yoshinari Yamamoto Takuya Suzuki |
| author_sort |
Nguyễn, Thị Thanh Tịnh |
| title |
Citrus limon peel powder reduces intestinal barrier defects and inflammation in a colitic murine experimental model |
| title_short |
Citrus limon peel powder reduces intestinal barrier defects and inflammation in a colitic murine experimental model |
| title_full |
Citrus limon peel powder reduces intestinal barrier defects and inflammation in a colitic murine experimental model |
| title_fullStr |
Citrus limon peel powder reduces intestinal barrier defects and inflammation in a colitic murine experimental model |
| title_full_unstemmed |
Citrus limon peel powder reduces intestinal barrier defects and inflammation in a colitic murine experimental model |
| title_sort |
citrus limon peel powder reduces intestinal barrier defects and inflammation in a colitic murine experimental model |
| publishDate |
2022 |
| url |
https://scholar.dlu.edu.vn/handle/123456789/818 |
| _version_ |
1786708702278975488 |