Physical, biochemical, and acute toxicity characteristics and accelerated aging of polyphenol/chlorophyll pullulate originating from maize by-product
The characteristics evaluation of the physic (sensory, swelling, disintegration, active ingredient release, bulk density, and mass uniformity), biochemistry, acute toxicity, and accelerated aging of polyphenol/chlorophyll pillulae was presented in the current study. Pillulae contained the poly...
Đã lưu trong:
Những tác giả chính: | , , , , , , , , , , , |
---|---|
Định dạng: | Journal article |
Ngôn ngữ: | English |
Được phát hành: |
Sapporo Ika Daigaku
2022
|
Những chủ đề: | |
Truy cập trực tuyến: | http://scholar.dlu.edu.vn/handle/123456789/976 |
Các nhãn: |
Thêm thẻ
Không có thẻ, Là người đầu tiên thẻ bản ghi này!
|
Thư viện lưu trữ: | Thư viện Trường Đại học Đà Lạt |
---|
id |
oai:scholar.dlu.edu.vn:123456789-976 |
---|---|
record_format |
dspace |
institution |
Thư viện Trường Đại học Đà Lạt |
collection |
Thư viện số |
language |
English |
topic |
antioxidant activity, chlorophyll, maize,pillulae, polyphenol |
spellingShingle |
antioxidant activity, chlorophyll, maize,pillulae, polyphenol Đặng, Xuân Cường Đỗ, Thi Hồng Tuoi* Lê, Trần Trọng Khôi Phạm, Đức Thịnh Nguyễn, Ngọc Bảo Huy Đặng,Thi Thanh Tuyền Nguyễn, Thi Kim Oanh Nguyễn, Le Thanh Tuyen Pham, Thanh Thuan Nguyễn, Thi Mỹ Lệ Nguyễn, Thị Thăng Long Hoàng, Đức An Physical, biochemical, and acute toxicity characteristics and accelerated aging of polyphenol/chlorophyll pullulate originating from maize by-product |
description |
The characteristics evaluation of the physic (sensory, swelling, disintegration, active
ingredient release, bulk density, and mass uniformity), biochemistry, acute toxicity, and accelerated
aging of polyphenol/chlorophyll pillulae was presented in the current study. Pillulae contained the
polyphenol/chlorophyll-rich concentrated extract of corn by-products in Khanh Hoa province,
Vietnam. The biochemistry characteristics were analysed, such as the content of polyphenol,
chlorophyll, ascorbic acid, thiamin, tocopherol acetate, alginate content, and Ca2+, bioactivities (total
antioxidant activity, reducing power activity, DPPH free radical scavenging activity, catalase
activity, formation inhibition of conjugated dienes, low-density lipoprotein-antioxidant activity).
Pillulae was tested for acute toxicity and accelerated aging for 30 days at 60oC and checked micro organism. The results showed that pillulae was non-toxic with a maximum dose of 75 pillulae/kg.
The sensory, swelling and active ingredient release of pillulae was good with bulk density (0.6
g/cm3
), and mass uniformity (140.12 mg) and polyphenol (31.95 mg), chlorophyll (110.02 µg),
ascorbic acid (20.27 mg), thiamin (0.22 mg), tocopherol acetate (1.2 mg), alginate content (20.46
mg), and Ca2+ (12 mg). The storage time of pillulae was estimated to be one year at 25oC through
accelerated aging storage for 30 days at 60oC, and only detection of total aerobic bacterial (2.8x102 CFU/g) on the 30th day of accelerated aging. Pillulae exhibited all various bioactivities (free radical
scavenging, conversion (Mo6+ and Fe3+), inhibition of conjugated diene formation for LDL, and
catalase activity), where highest reducing power activity (2,017.53). Pillulae could be support for
human health. |
format |
Journal article |
author |
Đặng, Xuân Cường Đỗ, Thi Hồng Tuoi* Lê, Trần Trọng Khôi Phạm, Đức Thịnh Nguyễn, Ngọc Bảo Huy Đặng,Thi Thanh Tuyền Nguyễn, Thi Kim Oanh Nguyễn, Le Thanh Tuyen Pham, Thanh Thuan Nguyễn, Thi Mỹ Lệ Nguyễn, Thị Thăng Long Hoàng, Đức An |
author_facet |
Đặng, Xuân Cường Đỗ, Thi Hồng Tuoi* Lê, Trần Trọng Khôi Phạm, Đức Thịnh Nguyễn, Ngọc Bảo Huy Đặng,Thi Thanh Tuyền Nguyễn, Thi Kim Oanh Nguyễn, Le Thanh Tuyen Pham, Thanh Thuan Nguyễn, Thi Mỹ Lệ Nguyễn, Thị Thăng Long Hoàng, Đức An |
author_sort |
Đặng, Xuân Cường |
title |
Physical, biochemical, and acute toxicity characteristics and accelerated aging of polyphenol/chlorophyll pullulate originating from maize by-product |
title_short |
Physical, biochemical, and acute toxicity characteristics and accelerated aging of polyphenol/chlorophyll pullulate originating from maize by-product |
title_full |
Physical, biochemical, and acute toxicity characteristics and accelerated aging of polyphenol/chlorophyll pullulate originating from maize by-product |
title_fullStr |
Physical, biochemical, and acute toxicity characteristics and accelerated aging of polyphenol/chlorophyll pullulate originating from maize by-product |
title_full_unstemmed |
Physical, biochemical, and acute toxicity characteristics and accelerated aging of polyphenol/chlorophyll pullulate originating from maize by-product |
title_sort |
physical, biochemical, and acute toxicity characteristics and accelerated aging of polyphenol/chlorophyll pullulate originating from maize by-product |
publisher |
Sapporo Ika Daigaku |
publishDate |
2022 |
url |
http://scholar.dlu.edu.vn/handle/123456789/976 |
_version_ |
1768305937399939072 |
spelling |
oai:scholar.dlu.edu.vn:123456789-9762022-10-14T02:46:28Z Physical, biochemical, and acute toxicity characteristics and accelerated aging of polyphenol/chlorophyll pullulate originating from maize by-product Đặng, Xuân Cường Đỗ, Thi Hồng Tuoi* Lê, Trần Trọng Khôi Phạm, Đức Thịnh Nguyễn, Ngọc Bảo Huy Đặng,Thi Thanh Tuyền Nguyễn, Thi Kim Oanh Nguyễn, Le Thanh Tuyen Pham, Thanh Thuan Nguyễn, Thi Mỹ Lệ Nguyễn, Thị Thăng Long Hoàng, Đức An antioxidant activity, chlorophyll, maize,pillulae, polyphenol The characteristics evaluation of the physic (sensory, swelling, disintegration, active ingredient release, bulk density, and mass uniformity), biochemistry, acute toxicity, and accelerated aging of polyphenol/chlorophyll pillulae was presented in the current study. Pillulae contained the polyphenol/chlorophyll-rich concentrated extract of corn by-products in Khanh Hoa province, Vietnam. The biochemistry characteristics were analysed, such as the content of polyphenol, chlorophyll, ascorbic acid, thiamin, tocopherol acetate, alginate content, and Ca2+, bioactivities (total antioxidant activity, reducing power activity, DPPH free radical scavenging activity, catalase activity, formation inhibition of conjugated dienes, low-density lipoprotein-antioxidant activity). Pillulae was tested for acute toxicity and accelerated aging for 30 days at 60oC and checked micro organism. The results showed that pillulae was non-toxic with a maximum dose of 75 pillulae/kg. The sensory, swelling and active ingredient release of pillulae was good with bulk density (0.6 g/cm3 ), and mass uniformity (140.12 mg) and polyphenol (31.95 mg), chlorophyll (110.02 µg), ascorbic acid (20.27 mg), thiamin (0.22 mg), tocopherol acetate (1.2 mg), alginate content (20.46 mg), and Ca2+ (12 mg). The storage time of pillulae was estimated to be one year at 25oC through accelerated aging storage for 30 days at 60oC, and only detection of total aerobic bacterial (2.8x102 CFU/g) on the 30th day of accelerated aging. Pillulae exhibited all various bioactivities (free radical scavenging, conversion (Mo6+ and Fe3+), inhibition of conjugated diene formation for LDL, and catalase activity), where highest reducing power activity (2,017.53). Pillulae could be support for human health. 55 10 1-11 2022-09-14T09:38:57Z 2022-09-14T09:38:57Z 2021-10 Journal article Bài báo đăng trên tạp chí thuộc SCOPUS, bao gồm book chapter http://scholar.dlu.edu.vn/handle/123456789/976 en Sapporo Medical Journal 0036472X [1] Do HB, Dang QC, Bui XC, Nguyen TD, Do TD, Pham VH, Vu NL, Pham DM, Pham KM, Doan TN, Nguyen T, Tran T. Medicinal plants and animals in Vietnam. Publishing: Science and Technology. (2006);2387 pages. [2] Parle M, Dhamija I. Zea maize: A modern craze. Int Res J Pharm. 2013;4:39-43. [3] Dang XC, Dang TTT, Do TK. Biophysical-chemistry characterization of alginate in brown algae species Sargassum duplicated. WJFST. 2020;4(1):17-22. [4] Nguyen DT, Vu NB, Nguyen XH, Dang TTT, Do TK, Nguyen KN, Nguyen NBH, Pham TT, Pham TT, Dang XC. The content, antioxidant activity, and structural characteristics of sodium alginate extracting from Sargassum polycystin grew in Vietnam: Effect of various extraction conditions. Journal of Pharmaceutical Research International. 2021;33(41A):197-206. [5] Shailja C, Shailendra D, Kamla KS, Placheril JJ, Praveen S. Vitamin C in disease prevention and cure: An overview. Indian J Clin Biochem. 2013;28(4):314–328. [6] Anitra CC, Silvia M. Vitamin C, and immune function. Nutrients. 2017;9:1211-1236. [7] Michael JR, Holly JD, Megan D, Kenneth BG, Brent A B, Gregory HG, Robert GC, Stephen EA. Vitamin E and C supplementation reduces oxidative stress and improves antioxidant enzymes, and positive muscle work in chronically loaded muscles of aged rats. Exp Gerontol. 2010;45(11):882–895 [8] Lukienko PI, Mel'nichenko NG, Zverinskii IV, Zabrodskaya SV. Antioxidant properties of thiamine. Bull Exp Biol Med. 2000;130(9):874-876. [9] Khadim RM, Al-Fartusie FS. Antioxidant vitamins and their effect on the immune system. J Phys: Conf Ser. 2021;1853:012065. [10] Pincemail J. Free radicals and antioxidants in human diseases. In: Analysis of free radicals in biological systems. Favier AE, Cadet J, Kalyanaraman B, Fontecave M, Pierre JL. (eds). Birkhäuser Basel. 1995; https://doi.org/10.1007/978-3-0348-9074-8_7. [11] Vietnam Pharmacopoeia Council.Ministry of Health. 2017; [12] Nikolett K, Oliver L, Judit D, Kristóf K, Miléna L, István A. Evaluation of drug release from coated pellets based on isomalt, sugar, microcrystalline cellulose inert cores. AAPS PharmSciTech. 2010;11(1):383-391. [13] Dang BTT, Vu NB, Ngo DN, Dang XC. Phytochemistry, nutrition component, vitamin, minerals, and antioxidant activity of three species Hydrocotyle sp. growth in Vietnam. International Medical Journal. 2020;25(03):1047-1056. Dang XC, Do THT, Le TTK, Pham DT, Nguyen NBH, Dang TTT, Nguyen TKO, … SMJ 10 [14] Cuong D. Antioxidant chlorophyll purification from maize leaves by liquid-to-liquid extraction method. JDDT. 2020;10(3):152-158. [15] Richardsona JC, Dettmarb PW, Hampsonb FC, Melia CD. A simple, high throughput method for the quantification of sodium alginates on oesophageal mucosa. Eur J Pharm Biopharm. 2004;57:299–305. [16] Nicoleta M, Simona D, Gabriel L. Spectrophotometric determination of ascorbic acid in grapes with the Prussian Blue reaction. Ovidius University Annals of Chemistry. 2012;23(2):174-179. [17] AOAC Official Method 953.17. Thiamine (vitamin B1) in grain products fluorometric (Rapid) method. [18] Herbert JK, Ching-Kuang C, Loring KB. Spectrophotometric method for determination of tocopherol in red blood cells. J Lipid Res. 1973;14:533-540. [19] ISO 6058:1984. Water quality – Determination of calcium content – EDTA titrimetric method [20] Dang BTT, Vu NB, Ngo DN, Dang XC. Polyphenol, chlorophyll: Optimization of extraction from Centella. Journal of Agriculture and Rural Development. 2020;1:93-99. [21] Vu NB, Dang XC, Phan TKV. Effcts of extraction conditions over the phlorotannin content and antioxidant activity of extract from brown algae Sargassum serratum (Nguyen Huu Dai 2004). Free radic antioxid. 2017;7(1):115-122. [22] Blois MS. Antioxidant determinations by the use of a stable free radical. Nature. 1958;26:1199–1200. [23] Mladenka P, Dubravka Š, Uroš Ž, Olivera Š, Bojana F, Miona B, Aleksandra M. Sensory profile and preference mapping of cookies enriched with medicinal herbs. Int J Food Prop. 2017;20(2):350-361. [24] Daniel G, Maria LM, Jéssica CBR. Sensory acceptability and physical stability evaluation of a prebiotic soy-based dessert developed with passion fruit juice. Ciênc Tecnol Aliment Campinas. 2012;32(1):119-125. [25] Benjamin C, Paul MF, Fidel T. Encyclopedia of food and health. Academic Press. 2016;4006 pages. [26] Selvamuthukumaran M., Yashwant VP. Flavor development for functional foods and nutraceuticals. CRC Press. 2019;292 pages. [27] Harry TL, Hildegarde H. Sensory evaluation of food: Principles and practices. Springer Science & Business Media. 2010;596 pages. [28] Ndidi CN, Elijah IN, Nelson AO, Patricia OO, Patrick OO. Eudragit E100 and polysaccharide polymer blends as matrices for modified-release drug delivery II: Swelling and release studies. Trop J Pharm Res. 2015;14(12):2163-2170. [29] Akbari BV, Dholakiya RB, Shiyani BG, Lodhiya DJ. Design and study on effect of hydrophilic polymers on release rate of baclofen sustained release matrix tablet. Research J Pharm and Tech. 2010;3(1):193-198. [30] Haroon R, Abdul S, Shahzeb K, Kamran AC, Fazli A, Mir AK, Sudhair A. Isolation and preliminary evaluation of Mulva Neglecta mucilage: a novel tablet binder. Braz J Pharm Sci. 2016;52(1):202-210. Sapporo Ika Daigaku APPORO MEDICAL UNIV , S 1, W 17, SAPPORO, JAPAN, 00000 |