Biologically active natural products: pharmaceuticals
Antibiotics, antineoplastics, herbicides, and insecticides often originate from plant and microbial defense mechanisms. Secondary metabolites, once considered unimportant products, are now thought to mediate plant defense mechanisms by providing chemical barriers against animal and microbial pred...
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| Главные авторы: | , |
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| Формат: | |
| Язык: | English |
| Опубликовано: |
CRC
2012
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| Предметы: | |
| Online-ссылка: | https://scholar.dlu.edu.vn/thuvienso/handle/DLU123456789/32006 |
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| Thư viện lưu trữ: | Thư viện Trường Đại học Đà Lạt |
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| Итог: | Antibiotics, antineoplastics, herbicides, and insecticides often originate
from plant and microbial defense mechanisms. Secondary metabolites, once considered
unimportant products, are now thought to mediate plant defense mechanisms by providing
chemical barriers against animal and microbial predators. This chemical warfare
between plants and their pathogens consistently provides new natural product leads.
Whether one studies toxins, herbicides, or pharmaceuticals, chemical compounds follow
basic rules of pharmacokinetics and pharmacodynamics. Chemical properties of a molecule
dictate its cellular and physiological responses, and organisms will act to modulate
those chemical responses. Discovery and development of new biologically derived and
environmentally friendly chemicals are being aggressively pursued by leading chemical
and pharmaceutical companies. Future successful development and approval of these new
chemicals will require knowledge of their common mechanisms in toxicology and pharmacology
regardless of their applications to plants or animals.
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