Peptides Inenergy Balance and Obesity
The prevalence of overweight and obesity has reached alarming proportions worldwide, placing this problem as one of the most relevant public health concerns. Given the current obesity epidemic, it is of paramount relevance to understand better the mechanisms underlying energy balance regulation. T...
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| Tác giả chính: | |
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| Định dạng: | Sách |
| Ngôn ngữ: | English |
| Được phát hành: |
CABI
2014
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| Những chủ đề: | |
| Truy cập trực tuyến: | https://scholar.dlu.edu.vn/thuvienso/handle/DLU123456789/36810 |
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| Thư viện lưu trữ: | Thư viện Trường Đại học Đà Lạt |
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| Tóm tắt: | The prevalence of overweight and obesity has reached alarming proportions
worldwide, placing this problem as one of the most relevant public health concerns. Given the current obesity epidemic, it is of paramount relevance to understand better the mechanisms underlying energy balance regulation. The survival
of higher organisms is dependent on the ability to procure, use and conserve
energy efficiently. From an evolutionary point of view, animals feed to satisfy
their immediate caloric and nutritional requirements from meal to meal, but also
to allow energy and nutrients to be stored in anticipation of high energy demands
or seasonal food shortages. Thus, food intake control involves the integration of
external environmental cues with multiple internal physiological signals, as well
as external social elements and hedonic influences.
It is now evident that energy balance is achieved through highly integrated
interactions involving the brain and the periphery, which are infl uenced by both
genetic and environmental factors. The past decades have witnessed an explosion in the identification and characterization of the many bioactive peptides
involved in energy homeostasis. In addition, most of the peptides related to
body-weight control have been shown to participate in other pathophysiological
manifestations, providing a molecular basis for obesity-associated diseases such
as type 2 diabetes mellitus, coronary heart disease, hypertension, dyslipidaemia,
stroke, osteoarthritis, sleep apnea and cancer, among others. |
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