Antimicrobial Drug Discovery Emerging Strategies
One of the scientific highlights of the 20th century was, without doubt, the development of successful prevention and control efforts for infectious diseases. After the development of penicillin and the subsequent development and synthesis of other antimicrobial agents, vaccines and ant...
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| Những tác giả chính: | , |
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| Định dạng: | Sách |
| Ngôn ngữ: | English |
| Được phát hành: |
CABI
2014
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| Những chủ đề: | |
| Truy cập trực tuyến: | https://scholar.dlu.edu.vn/thuvienso/handle/DLU123456789/37136 |
| Các nhãn: |
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| Thư viện lưu trữ: | Thư viện Trường Đại học Đà Lạt |
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| Tóm tắt: | One of the scientific highlights of the 20th
century was, without doubt, the development
of successful prevention and control efforts
for infectious diseases. After the development
of penicillin and the subsequent development
and synthesis of other antimicrobial agents,
vaccines and antiseptics, victory against path-
ogens was declared (Sigerist, 1971). By the
1980s, pharmaceutical companies were con-
vinced that there were already enough anti-
microbial agents – the feeling at the time was
that research should get ready to ‘close the
book on infectious diseases’ and the empha-
sis was shifted to other clinical problems such
as cancer, diabetes and heart disease.
However, the extensive and inappropri-
ate use of antimicrobial agents gradually led
to the development of pervasive resistance.
Penicillin was first put into widespread use in
the early 1940s, and by 1944, half of all clini-
cal Staphylococcus spp. isolates were resistant
to this proclaimed ‘miracle drug’ (Livermore,
2000). Today, infectious disease is the second
most important killer in the world, third in
developed nations and fourth in the USA behind
heart disease, cancer and stroke (Vicente et al.,
2006; Kraus, 2008). Worldwide, 17 million peo-
ple die each year from bacterial infections and
numerous others from viral, fungal and para-
sitic diseases (Butler and Bush, 2006). |
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