Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene
Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes ident...
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| Główni autorzy: | , , |
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| Format: | Książka |
| Język: | English |
| Wydane: |
Springer
2015
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| Hasła przedmiotowe: | |
| Dostęp online: | https://scholar.dlu.edu.vn/thuvienso/handle/DLU123456789/57955 |
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| Thư viện lưu trữ: | Thư viện Trường Đại học Đà Lạt |
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| Streszczenie: | Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. |
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