Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene
Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes ident...
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2015
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oai:scholar.dlu.edu.vn:DLU123456789-579552023-11-11T05:54:09Z Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene Kashyap, Amita Bujamma, D Babu M, Naresh Bioinorganic chemistry Small cell lung cancer Life Sciences Biochemistry Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. 2015-09-03T08:28:33Z 2015-09-03T08:28:33Z 2015 Book 978-981-4585-08-8 https://scholar.dlu.edu.vn/thuvienso/handle/DLU123456789/57955 en application/pdf Springer |
| institution |
Thư viện Trường Đại học Đà Lạt |
| collection |
Thư viện số |
| language |
English |
| topic |
Bioinorganic chemistry Small cell lung cancer Life Sciences Biochemistry |
| spellingShingle |
Bioinorganic chemistry Small cell lung cancer Life Sciences Biochemistry Kashyap, Amita Bujamma, D Babu M, Naresh Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene |
| description |
Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. |
| format |
Book |
| author |
Kashyap, Amita Bujamma, D Babu M, Naresh |
| author_facet |
Kashyap, Amita Bujamma, D Babu M, Naresh |
| author_sort |
Kashyap, Amita |
| title |
Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene |
| title_short |
Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene |
| title_full |
Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene |
| title_fullStr |
Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene |
| title_full_unstemmed |
Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene |
| title_sort |
bioinformatics of non small cell lung cancer and the ras proto-oncogene |
| publisher |
Springer |
| publishDate |
2015 |
| url |
https://scholar.dlu.edu.vn/thuvienso/handle/DLU123456789/57955 |
| _version_ |
1819834011871084544 |