Antioxidant and Hepatoprotective Effects of Kadsura coccinea Stem Extract on Oxidative Damage on HepG2 Cells
Background: Reactive oxygen species (ROS) contribute to increased intracellular oxidative stress, which has detrimental effects on normal cells and reduces antioxidant levels. This oxidative stress, particularly in the liver, causes inflammation, which leads to the development of acute and chronic...
Đã lưu trong:
| Những tác giả chính: | , , , , , |
|---|---|
| Định dạng: | Journal article |
| Ngôn ngữ: | Korean |
| Được phát hành: |
Korean Society of Medicinal Crop Science
2024
|
| Những chủ đề: | |
| Truy cập trực tuyến: | https://scholar.dlu.edu.vn/handle/123456789/3599 |
| Các nhãn: |
Thêm thẻ
Không có thẻ, Là người đầu tiên thẻ bản ghi này!
|
| Thư viện lưu trữ: | Thư viện Trường Đại học Đà Lạt |
|---|
| Tóm tắt: | Background: Reactive oxygen species (ROS) contribute to increased intracellular oxidative stress,
which has detrimental effects on normal cells and reduces antioxidant levels. This oxidative stress,
particularly in the liver, causes inflammation, which leads to the development of acute and chronic
liver diseases. Hence, substances with the ability to efficiently reduce ROS levels and oxidative
stress are needed.
Methods and Results: Kadsura coccinea stem extract exhibited a concentration-dependent
antioxidant activity and imporved alcohol dehydrogenase and aldehyde dehydrogenase effects. Noncytotoxic effects and increased cell activity were observed in HepG2 cells treated with K. coccinea
stem extract under conditions of hydrogen peroxide induced hepatotoxicity. Additionally, the extract
effectively reduced ROS levels, as confirmed by 2′,7′-dichlorodihydrofluorescein diacetate (DCFHDA) assay in HepG2 cells simultaneously exposed to hydrogen peroxide and the K. coccinea stem
extract. mRNA expression analysis revealed elevated levels of antioxidant enzymes, including
superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1), and catalase (CAT).
Conclusions: These findings reveal the potential therapeutic value of K. coccinea stem extract for
oxidative stress related liver disorders. |
|---|