Antioxidant and Hepatoprotective Effects of Kadsura coccinea Stem Extract on Oxidative Damage on HepG2 Cells
Background: Reactive oxygen species (ROS) contribute to increased intracellular oxidative stress, which has detrimental effects on normal cells and reduces antioxidant levels. This oxidative stress, particularly in the liver, causes inflammation, which leads to the development of acute and chronic...
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Korean Society of Medicinal Crop Science
2024
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oai:scholar.dlu.edu.vn:123456789-35992024-10-04T08:26:36Z Antioxidant and Hepatoprotective Effects of Kadsura coccinea Stem Extract on Oxidative Damage on HepG2 Cells 흑노호 줄기 추출물의 항산화 활성 및 산화적 손상에 따른 간세포보호 효과 Joon Hee Han Min Hong Hoàng, Việt Bách Khoa Lương, Văn Dũng Tae Hyung Kwon Soo Ung Lee Kadsura coccinea Antioxidant Hepatoprotective Effects Hepatoprotective Effects Background: Reactive oxygen species (ROS) contribute to increased intracellular oxidative stress, which has detrimental effects on normal cells and reduces antioxidant levels. This oxidative stress, particularly in the liver, causes inflammation, which leads to the development of acute and chronic liver diseases. Hence, substances with the ability to efficiently reduce ROS levels and oxidative stress are needed. Methods and Results: Kadsura coccinea stem extract exhibited a concentration-dependent antioxidant activity and imporved alcohol dehydrogenase and aldehyde dehydrogenase effects. Noncytotoxic effects and increased cell activity were observed in HepG2 cells treated with K. coccinea stem extract under conditions of hydrogen peroxide induced hepatotoxicity. Additionally, the extract effectively reduced ROS levels, as confirmed by 2′,7′-dichlorodihydrofluorescein diacetate (DCFHDA) assay in HepG2 cells simultaneously exposed to hydrogen peroxide and the K. coccinea stem extract. mRNA expression analysis revealed elevated levels of antioxidant enzymes, including superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1), and catalase (CAT). Conclusions: These findings reveal the potential therapeutic value of K. coccinea stem extract for oxidative stress related liver disorders. 32 1 1-9 2024-10-03T07:37:04Z 2024-10-03T07:37:04Z 2024-02-05 Journal article Bài báo đăng trên tạp chí thuộc SCOPUS, bao gồm book chapter https://scholar.dlu.edu.vn/handle/123456789/3599 10.7783/KJMCS.2024.32.1.1 ko Korean Journal of Medicinal Crop Science 2288-0186 Background: Reactive oxygen species (ROS) contribute to increased intracellular oxidative stress, which has detrimental effects on normal cells and reduces antioxidant levels. This oxidative stress, particularly in the liver, causes inflammation, which leads to the development of acute and chronic liver diseases. Hence, substances with the ability to efficiently reduce ROS levels and oxidative stress are needed. Methods and Results: Kadsura coccinea stem extract exhibited a concentration-dependent antioxidant activity and imporved alcohol dehydrogenase and aldehyde dehydrogenase effects. Noncytotoxic effects and increased cell activity were observed in HepG2 cells treated with K. coccinea stem extract under conditions of hydrogen peroxide induced hepatotoxicity. Additionally, the extract effectively reduced ROS levels, as confirmed by 2′,7′-dichlorodihydrofluorescein diacetate (DCFHDA) assay in HepG2 cells simultaneously exposed to hydrogen peroxide and the K. coccinea stem extract. mRNA expression analysis revealed elevated levels of antioxidant enzymes, including superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1), and catalase (CAT). Conclusions: These findings reveal the potential therapeutic value of K. coccinea stem extract for oxidative stress related liver disorders. Korean Society of Medicinal Crop Science Hàn Quốc |
| institution |
Thư viện Trường Đại học Đà Lạt |
| collection |
Thư viện số |
| language |
Korean |
| topic |
Kadsura coccinea Antioxidant Hepatoprotective Effects Hepatoprotective Effects |
| spellingShingle |
Kadsura coccinea Antioxidant Hepatoprotective Effects Hepatoprotective Effects Joon Hee Han Min Hong Hoàng, Việt Bách Khoa Lương, Văn Dũng Tae Hyung Kwon Soo Ung Lee Antioxidant and Hepatoprotective Effects of Kadsura coccinea Stem Extract on Oxidative Damage on HepG2 Cells |
| description |
Background: Reactive oxygen species (ROS) contribute to increased intracellular oxidative stress,
which has detrimental effects on normal cells and reduces antioxidant levels. This oxidative stress,
particularly in the liver, causes inflammation, which leads to the development of acute and chronic
liver diseases. Hence, substances with the ability to efficiently reduce ROS levels and oxidative
stress are needed.
Methods and Results: Kadsura coccinea stem extract exhibited a concentration-dependent
antioxidant activity and imporved alcohol dehydrogenase and aldehyde dehydrogenase effects. Noncytotoxic effects and increased cell activity were observed in HepG2 cells treated with K. coccinea
stem extract under conditions of hydrogen peroxide induced hepatotoxicity. Additionally, the extract
effectively reduced ROS levels, as confirmed by 2′,7′-dichlorodihydrofluorescein diacetate (DCFHDA) assay in HepG2 cells simultaneously exposed to hydrogen peroxide and the K. coccinea stem
extract. mRNA expression analysis revealed elevated levels of antioxidant enzymes, including
superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1), and catalase (CAT).
Conclusions: These findings reveal the potential therapeutic value of K. coccinea stem extract for
oxidative stress related liver disorders. |
| format |
Journal article |
| author |
Joon Hee Han Min Hong Hoàng, Việt Bách Khoa Lương, Văn Dũng Tae Hyung Kwon Soo Ung Lee |
| author_facet |
Joon Hee Han Min Hong Hoàng, Việt Bách Khoa Lương, Văn Dũng Tae Hyung Kwon Soo Ung Lee |
| author_sort |
Joon Hee Han |
| title |
Antioxidant and Hepatoprotective Effects of Kadsura coccinea Stem Extract on Oxidative Damage on HepG2 Cells |
| title_short |
Antioxidant and Hepatoprotective Effects of Kadsura coccinea Stem Extract on Oxidative Damage on HepG2 Cells |
| title_full |
Antioxidant and Hepatoprotective Effects of Kadsura coccinea Stem Extract on Oxidative Damage on HepG2 Cells |
| title_fullStr |
Antioxidant and Hepatoprotective Effects of Kadsura coccinea Stem Extract on Oxidative Damage on HepG2 Cells |
| title_full_unstemmed |
Antioxidant and Hepatoprotective Effects of Kadsura coccinea Stem Extract on Oxidative Damage on HepG2 Cells |
| title_sort |
antioxidant and hepatoprotective effects of kadsura coccinea stem extract on oxidative damage on hepg2 cells |
| publisher |
Korean Society of Medicinal Crop Science |
| publishDate |
2024 |
| url |
https://scholar.dlu.edu.vn/handle/123456789/3599 |
| _version_ |
1813142645172600832 |